LEISHMANIASIS

    • Puppy

    LEISHMANIASIS

    Hello again to all of you -long time no post -I posted under the name dragona but I lost all my details so had to create a new account. Some of you may or may not remember my previous posts about Vito -his immune mediated vasculitis,nose bleeds, demodex, cruciate problems. Callie here gave me TONS of advice, all of which I followed, unfortunately all to no avail. http://community.dog.com/forums/p/31425/409896.aspx#409896 General unwellness. After NUMEROUS financially crippling visits to my vet and TWO referrals to University Vet Hospital, we have a definitive diagnosis. Leishmaniasis. To say I am devastated is the understatement of the millennium. We were at the UVHosp last July and we saw the specialist dermatologist who diagnosed immune mediated vasculitis - treatment plan was a long course of antibiotics and prednisolone. The pred has been on and off since.When we saw the dermatologist it was 4 months after a cruciate repair on both legs. They were not healing properly. The op had to be repeated, again on both legs. This was also unsuccessful,apparently due to the high dose of pred he was taking daily. I am LIVID that the derm, knowing Vitos history and all the clinical signs, did not consider the possibility of Leishmaniasis and did not test for it. I understand that his symptoms are many, but after doing my own research, quite frankly there is nothing else it could possibly have been. Fast forward to two months ago -Vitos knees creak very loudly, he is in pain, can hardly walk still on pred so I can't give him metacam, one leg is constantly held up, just a bloody nightmare. I had to wait for an appointment for the Uni and went last Monday where I saw the ortho vet -he took x-rays and Vito's knees are totally shot -bone on bone. Massive swelling around the joints. He aspirated some of the fluid and said he was testing for infection with a view to *flushing * the joints, said it would ease his pain a little. I was given Atopica and Tramadol for pain. The following night he called me and gave me the diagnosis. Back up there the next day for more x-rays, skin biopsies, fluid from the rest of his joints need to be tested. He said that he had never come across a case of it before.It is the cause of each and every one of Vito's problems. Poly arthritis, skin lesions, muscle wasting at the temples, nosebleeds, everything. I am honestly in total shock -I can hardly BELIEVE that this poor dog has been suffering for nearly TWO YEARS and it was all due to a bite from a sand fly. Even worse, that it was not picked up on by anyone until now. I am trying to find out as much as I possibly can, I am in Ireland and the drugs used to treat it are actually not available here! I am waiting to hear back from UVHosp tomorrow for treatment plan.
    • Moderators
    • Gold Top Dog

     What a nightmare - poor poor Vito.  I really don't know what to say, I have never heard of this disease.

    What is the prognosis now? Can he heal up and be OK?  Please let us know

    wishing Vito some peaceful sleep and strong healing powers 

    • Puppy
    Thanks this whole journey has been a complete , total and utter nightmare. I spoke to the vet again today and I now have to wait as it is the first documented case of it here in Ireland(only one other, but post mortem therefore untreated) and they have to obtain a special license in order to import the drugs he needs. I am so anxious it is unbearable. The treatment plan is daily injections of a drug called Glucantime for 40 days(which more than likely I will have to administer) with combined Allopurinol tablets, probably for life . This will improve his clinical symptoms but the poly arthritis is obviously irreversible and his knees are screwed I know it is HIGHLY unlikely, but does anyone have any experience of this?? I only know that it is endemic in only certain parts of the U.S and I cannot find anyone else to talk to about it I can only assume Vito was bitten by a sandfly between the ages of 5 and 11 months when we were living in Italy. He showed no sign of a bite, no scratching, swelling, NOTHING.When he was about 2 1/2 he had a small surgery to remove a fatty lump under his jaw -a few weeks after that we started with the hair loss, dandruff,sore ear tips and tail, anemia, nosebleeds, and a myriad of other symptoms. My vet obviously had NO idea what was going on and Vito was treated for demodex with no results. Then he ruptured both cruciates and had two ops, both unsuccessful. Very bad arthritis, skin sores,deformed claws, I could go on and on. I appreciate that my own vet was stumped but I feel that the Hospital dermatologist, having all our history and the poor dog having a nosebleed in his presence,, should have considered the possibility and had him tested.Multiple skin biopsies were done and the diagnosis this time last year was immune mediated vasculitis, cause unknown. I did question the vet I saw this time at the hospital, and his explanation was(I don't actually believe this) that the skin biopsies taken last year showed no evidence of leishmania as he had not yet started prednisolone therapy.I am still waiting on a call to tell me the drugs are available. I know that they will only resolve some of the problems -his joints(only the stifles thank god)are shot,I'm not sure yet whether they might improve the pain levels in his knees, the only option is a knee replacement, and it is not viable for dogs. I have to think very long and hard.
    • Puppy
    Here is a link to photos :( http://picasaweb.google.co.uk/gvrossi
    • Moderators
    • Gold Top Dog

    Crying

    Oh Vito - may you get relief soon baby