calliecritturs
Posted : 7/2/2006 7:38:42 AM
Sandra -- go to Wal-mart in the pharmacy section -- they have a BUNCH of these little pill thingamys - get two of each color for each of you! IT WORKS. They're cheap -- like $1.50 each and they come in different colors and styles -- just get an AM and PM of each color for each dog and there are a couple of styles that are AM/PM in one case. It saves TON of time (and sanity).
See that's what was happening last week -- Billy's red blood cells were dying MUCH faster than they were appearing and they found early this week it was 'because' the IMHA was attacking in the bone marrow. Poor Hunter couldn't keep the meds down -- and it took like almost 2 full weeks for Billy's body to build up enough cyclosporin IN the body to reach a level where the immune system said 'oh really? ok -- I can stop now'.
They almost did the bone marrow draw last week -- and that wouldn't have told them THIS (because he wasn't on cyclosporin then). They didn't release him this week until they were sure his body *was* manufacturing red blood cells fast enough AND that the baby red blood cells were actually making it all the way into the blood in the body and not just dying in the bone marrow like before.
Even 3 years ago no way could we have afforded this kind of testing. And, in fact, it was simply that we got a small windfall literally the day before this all happened, or we couldn't have done this either. This snagged all my nice Christmas bonus AND all of that adn the rest we could suck up -- but had we not had him at the University where they have kajillions of tests he wouldn't have responded to this. I suspect, and no one has done studies on this, that somehow buffy coat cockers are far more prone to IMHA zooming into the bone marrow. In most dogs it only attacks in the bloodstream and the steroids get the body to get with the program faster. It's ONLY because Billy is such a little piggie (and he'll eat even when he's not feeling well simply because this dog has the mindset that food's gonna make EVERYTHING better!! He's battled the bulge ever since I've had him and this time it saved his life).
I wish they would test deeper with IMHA and figure out how to get the cyclosporin into the body in the desired concentration FASTER -- like with injections or something (gee, don't I sound like a research vet? Not) IN order to make this treatable on a broader scale they need to make the treatment do-able for dogs like Hunter.
And honestly we still don't know that Billy's on target -- so much depends on whether or not his blood WILL stay now. They took away the stomach protectant (the sucrylfate) because it was interfering with his absorption of the steroids. That scares me to pieces because it pushes his risk up.
At this point they don't even want us to test his hematacrit every day simply because every time they draw blood there's the potential for a tiny blood clot to form INSIDE the blood vessel, break off and become a bigger one that will kill him. The risk of the stroke is still as big as the risk that his body might not overcome the anemia sufficiently.
sorry, for most of you this is more information than you need -- but IMHA is SO huge right now -- they're seeing many new cases every week. In Billy's case it was triggered either by the exposure to the tick disease or for no reason other than he's a buffy coat cocker (over 1/3 of all dogs who GET IMHA are cockers and most of the deaths ARE cockers because they respond so poorly). In Hunter's case, he got IMHA because of the ProHeart 6 that weakened him (and Sandra, I think, has been told why that happened). But vaccines, drugs, other major infections, thyroid problems, etc. all can cause IMHA. In fact, they're pretty much saying now that anything can cause IMHA.
It's so sad that the survival rate for this is SO poor. It's like the survival rate for heartworm disease *used* to be. 15-20 years ago IF your dog got hw disease they died. My old vet, who was on the research and development team for ivermectin 20 years ago, used to tell me stories that he'd walk in and have 30 dogs to treat that day and he'd often lose ALL 30.
My point is that as time goes on they'll figure out how to treat this IMHA too, but it's a nasty one when so many dogs, EVEN ones like Hunter who were treated fast, can't make it.
My heart so grieves for Sandra -- but she's taught me so much about this stuff. Thank you again Sandra -- you've helped Billy with what you've told me. And I know Hunter is up there on Rainbow Bridge wagging his tail. Thanks Hunter -- you're one of my heros just like your Mom.