M.W.Lewis
Posted : 6/20/2006 3:29:01 PM
ORIGINAL: sooner
I don't understand the reasoning behind the steroid and I don't want to give it if it is not necessary.
The Pred is a synthetic anti-inflammatory hormone. Dogs, cats, horses, humans- we all make a natural one called cortisol. So it calms the cellular inflammation that has taken place from the allergic reaction. A dog who responds favorably to Pred should probably have adrenal function tested to see if it is fulfilling a hormonal deficiency that effects immune function. Vets prescribe it for relief but sometimes are actually temporarily correcting a hormone deficiency unknowingly. Once the Pred is out of the body the deficiency may return if the adrenals are not performing normally.
Too little cortisol in itself also effects thyroid function since it's needed to convert T4 into T3 so the body can use that thyroid hormone.
Many dogs with immune issues often show abnormal hormone levels of both adrenal and thyroid. This in turn, effects immune function as the hormones govern much of the immune system.
I learned this after finding out that my dog had very poor immune function and often had infections and skin issues. A diet free of allergens helped her but not enough to live comfortably. She was given up to rescue by her previous owners probably for this reason and that's when we adopted her. Nothing seemed to help enough. We tried several prescription and OTC antihistamines, she was even treated for mites with ivermectin despite clean scrape, we had various anti-inflammatory shamoos and leave in treatments, Gentocin spray, EFA caps, even Prednisone which helped but not always- none of it really helped enough for her to be comfortable or alleviate all of the various infections that popped up one after the other. The baths did help a bit to get rid of some of the bacteria on her skin so fewer antibiotics were needed, the diet helped a bit too and the fish oil most likely also yet not enough to be normal or lead a normal life. But testing for and then correcting her thyroid and adrenal levels helped the most. If she had normal levels, the rest of it (diet, fish oil, antihistamines) probably would have been sufficient to give her a normal life.
She takes natural hydrocortisone daily. It's plant derived and is only enough to fulfill her hormonal levels. Unfortunately, the high doses of Pred and others often prescribed are sometimes counter productive as too much cortisol is also immune suppressive, just as too little is. A high dose can quickly quell the fire of the immune issue at hand and that is neccessary sometimes to try to get a grip and then systematically figure out what's going on within the immune system. It can give a much needed break to a suffering animal but in the long run the immune system needs some looking into.
When my dog had abnormal hormone levels her antibody levels (also called immune globulin) were also all abnormal also. As her hormone levels began to normalize so did her antibody levels.
It was something to see them rise closer to normal range as the hormone levels did also.She can still get thrown off with food allergies but her immune function is considerably better for the last several years. After trying so many things form the outside, and even inside with diet, we really found the best results form correcting her thyroid and adrenal levels. If you do test thyroid, btw, you may as well test adrenal.
The drug given for hypothyroidism isn't reccomended for use anyway in dogs with unaddressed adrenal insufficiency. So checking both may be prudent as they often can go hand in hand anyway.
So I can't really tell you to use it or not, but if you give it and he does respond favorabluy then I would definitely have his adrenal hormones tested, not just cortisol, but the aldersterone and importantly the adrenal estrogen (males and females both produce this). My dogs glands actually were producing too much adrenal estrogen also and it was very limiting to the immune system. Once her cortisol was corrected the estrogen leveled out on it's own, no help needed.
Another option if you do go with a holistic vet is to try to boost immune function with glandulars if you find the adrenals and thyroid are not functioning well. There are holistic vets though who do the Plechner protocol that my dog is on for Endocrine-Immune Imbalance. Carvel Tiekert is on (founder of AHVMA) tests for it and uses the protocol, there are some other holistic vets on the site [link
http://www.drplechner.com]www.drplechner.com[/link] too.
OK, I've written a book here, I never meant to be so long winded!
More or less, if you do not find the source of the immune issues, perhaps look into testing thyroid and adrenal glands. If you are able to find a remedy or a diet that helps that is definitely easier, otherwise the testing may give deeper insight.