jessies_mom
Posted : 12/7/2006 3:57:08 PM
As for false negatives, I sort of don't get that part. On our results, it only showed the things she tested positive to, so I guess everything else was negative, and some of those might be false negatives??? Doesn't make sense in our case. Now, false postives I could see, and I wouldn't doubt the possibility of that.
This explains why skin testing is better and why blood testing can give false negatives; [link
http://www.hillary.net/school/dermatology/derm.lec.11.09.98]http://www.hillary.net/school/dermatology/derm.lec.11.09.98[/link] ;
" the problem for many years with these
tests was that we didn't have just patient IgE binding allergens. there
is a lot of crossreactivity with IgG, and non-allergic patients looked
allergic on these tests. IgG doesn't cause mast cell degranulation and
Tcell reactivity to allergens. So tests could look positive on
everything, and that isn't useful at all. but, we didn't need to sedate
dogs, clip them, or use drug withdrawal. skin tests are expensive to do
and you have to do a lot of animals to recoup startup costs, and so
people used these blood tests a lot.
currently, we get a lot of false
negatives during the off season. when testing how much IgE is in the
blood, if the allergen has not been around for 6 mos, the level of Ab
will be low in the serum - but it stays high in the skin (and pulmonary
tissues). "
I agree though that labs are working to make the blood tests more accurate.