Posted : 2/11/2010 6:39:44 PM
Topicals come in two types -- Vectra and Frontline aren't systemic. They settle in the hair follicles and skin pores but they don't go into the bloodstream.
Topicals like Advantage-Multi and REvolution start out on the skin but they sink into the bloodstream thru the skin and stay there for months. You don't know when they really have left the body and in re-applying it when it seems like you need it or monthly you can be seriously over-dosing the dog. That's typically what caused so many deaths with ProHeart 6.
You may want to check out http://www.dogsadversereactions.com -- and see how a lot of these have so many reactions.
some pills -- like capstar -- kill fast and then exit the body. But most of them, like the systemic topicals, rely on the parasite biting the dog in order to die.
First off, that doesn't even make sense to me -- if the parasite bites the dog it can transmit disease. So why do you want it to bite to kill?
Second -- the whole idea of feeding my dog a pesticide just scares me -- knowing the predisposition it tends to give the dog to diseases like auto-immune stuff and general adverse reactions.
Comfortis in particular really worries me --
A. It was only tested on beagles. Back when they tested ivermectin they only tested it on greyhounds. But then it took years after they released it to the public to discover that it caused problems in collies, shelties and herding breeds.
Comfortis is VERY like ivermectin -- it kills by disrupting the nervous system of the parasites and, in fact, has potential problems when given WITH ivermectin (HeartGuard? Iverhart?)
B. One of the specific adverse reactions that worries me the most is that it causes seizures -- and with the nervous system involvement that doesn't surprise me a bit. Not seizures in dogs that were already seizure dogs. Seizures in a random study of healthy dogs. NOT good in my book.