Posted : 12/24/2010 1:52:01 AM
He has been taking it for about 6 months, initially at 100 mg/day, amplified with ketaconazole. We're down to one 100mg every other day, still amplified. They checked his urine, did a bile acid test, and an abdominal u/s. All are fine. They ran a much more complete blood panel, and everything was normal except the albumin. They did two albumin readings, 2 weeks apart. The first was 2.1, and the second was 2.3. At this lab, 2.5 and up is ok. The only change was that I cut the Cyclosporine in half (down to the 2 every other day dose) and increased his food slightly.
He is a rescue that we've had about a year. We figure he's about 10 years old. No physical symptoms at all, he seems to feel fine. No vomiting or diarrhea. He was 83 lbs when we got him and gaining fast, and correct weight is about 60 lbs. He is down there now, so I want to make sure we don't overshoot it which is why I increased his food a bit. I'm a little worried that the fast weight loss might be contributing, but it was all under the guidance of our vet who monitoring his weight regularly. He has food allergies in addition to his airborn allergies, so he eats only ZD Ultra. I'm a little concerned that it might not be nutritionally complete, but if the low albumin is caused by GI tract issues, changing his food may be a bad idea. Likewise with the Cyclosporine -- if the problem is GI irritation due to allergies, reducing or eliminating it could cause a flair up. Before the Cyclosporine, his ears and chin had chronic sores, and he chewed his feet raw.
One other complicating factor: he has at least one mast cell skin tumor, and perhaps more. They are tiny and not changing, so we are monitoring those.
The vet feels we've ruled out liver and kidney disease, so she is focusing on the GI tract now. She had me bring in a fecal and worm him with a 5 day course of Panacur regardless of fecal results. Next they are talking about doing an endoscopic biopsy and evaluation of his GI tract to see if it could be IBD or Lymphangiectasia.
I'm just really suspicious of the Cyclosporine, and this article about it and albumin levels in rats just increases my concern:
I am really interested in hearing any thoughts about this or if anyone has been told that Cyclosporine is counter-indicated in cases of high albumin.