OK, in my personal opinion, and in my experience as a breeder and foster mom to new litters, big combo shots are pretty awful. Most of the stuff in them is not needed and when you give a zillion shots rolled into one you give the immune system one heck of a whallop and IF there is a reaction, it's hard to tell which one.
I ONLY do parvo and distemper and that is what Dr. Dodds advises. I know that her protocal has changed slightly, but it was modified live virus parvo and distemper at 9 weeks, 12 weeks and between 15-20 weeks, with rabies not before 24 weeks.
A house without fur is not a home.
Glenda