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AIHA disease

Last post 03-11-2009 2:11 PM by Tashmoo5454. 13 replies.
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  • 02-26-2009 11:20 AM

    • Elie
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    • Joined on 02-26-2009
    • Posts 8
    • Points 185

    AIHA disease

    I had to put my 3 yr old border collie (Rosie) to sleep Feb 23 and I am devastated. She was playing, eating, running, barking, and then 2 days later she didn't look too good and did not eat her dinner. Next day (Monday Feb 16) she looked worse so I took her to vet who diagnosed anemia (jaundice in eyes & ears, whitish gums) and put her on prednisone. Got 2nd opinion next day and same diagnosis, same treatment. Then 4 days later she started perking up, PCV level went up to 20 (from 14) and was on right track, started eating next day, and then that evening she seemed fussy. Next day (Sunday) she would not eat, seemed good at times but then worn out, went outside to piddle, came in and looked like she was going to pass out. Then she settled down and her breathing seemed more normal. All of a sudden her breathing became labored, was going to rush her to hospital but then again the breathing settled down and she was ok. About an hour later same thing happened and then I rushed her to hospital, they put her on oxygen and gave IV fluids. She perked up. Even though her PCV level was 24 they advised giving her a transfusion just to help her along. Everything was getting better rest of day and overnight. They also gave her a baby aspirin around noon to ward off any blood clots. Then I visited her around 3pm (Monday Feb 23) and gave her some chicken from home which she ate. She was looking good, alert, walking straight, and getting opinionated with the vet techs. Only thing they were concerned about was her breathing when she was laying down. It was fine when she was up and walking but as soon as she laid down the breathing was labored. Her pulse-ox was fine though. Three hours later they called me and said she was going downhill, her breathing was very labored, was put into oxygen cage again and gave me all the options for treating her, keeping her going yet no guarantee of her surviving. I agreed to let her go. They gave her some morphine to calm her down. Since I was at work, I went up there at midnight to see her and to decide whether to keep treating her, trying anything in the world to make her better, taking her home, etc. Once I saw her in the oxygen cage I realized how distressed she really was. She was panting so hard and looked miserable. I went over all the options again with the vet and I know they were all tired of my stupid questions over and over again but I couldn't face this, couldn't deal with it, and blaming myself for all of this happening to my beloved girl. I was in contact with my own vet and she also advised letting her go, said even with more extensive tests and misery for her, she would probably not survive another day, couple of days, or even 3 months at the most. She said it wouldn't be fair to her to put her thru all of that when she could never be a normal dog again and be in total misery. So I decided to put her to sleep, never did that before in my life and was devastated. I really feel that I let her go, all my fault for this happening to her, because I did not act one day when I saw her pale tongue hanging out after she had been running at full tilt for awhile, barking her head off, and gasping when she came running in for water. She was fine after she settled down and still continued to run, bark, and be her old self. When I come home from work tired and cranky I get annoyed when she is jumping against me but all she wanted was attention and I would not give it but then later on would give it. I feel that she was taken away from me because I did not give her the attention she craved. I loved her with all my heart, have never hurt an animal, have always treated them like they were my babies no matter how old they were. I wanted her to be with me for another 15 years. She was like sunshine, so happy, so cheerful all the time and she was exactly like my first border collie who passed away Feb 23, 2005. I adored her and always wanted another dog like her so when Rosie came into my life, she turned out just like her, slept in the same places that Christie slept outside under the bushes (whenever she was out) and was a runner and a barker, happy go lucky. I hate the month of February every year and now Rosie died same time. Has anyone ever experienced the same feeling of guilt, negligence, stupidity, loss of control over what was happening, not recognizing signs, and devastation over the passing of someone so beloved. She was the breath of sunshine in my life and I am beside myself with grief and anger at myself. I also have a 9 yr old border collie but she never had the sunshine personality of Rosie. Also have a 2 yr old cat who is also grieving because his best friend and playmate was Rosie.
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  • 02-26-2009 11:36 AM In reply to Elie

    Re: AIHA disease

    Unfortunately, several of us on this board are VERY well acquainted with AIHA (auto-immune hemolytic anemia) or, as it is also now known as IMHA (immune-mediated hemolytic anemia).

    In fact, there is a 23+ page thread running right now on this, and I started another one yesterday for a fellow named Steve who had to put his golden to sleep yesterday because of ... yep, IMHA. 

    It is a VICIOUS disease.  Unbelievably expensive and often the drugs can add their own fatality (they can wind up with a stroke or embolism simply because of the steroids), and like all auto-immune disease it can re-cur or morph into another auto-immune disease ANY TIME AT ALL.

    My Billy (that's him in my signature) is an IMHA survivor (very rare for buffy cockers) and I've tried hard to be support for folks going thru this.

    Your guilt is completely normal and understandable -- it is virtually impossible to actually know HOW to treat this, how to treat it and have your dog actually survive the drugs themselves AND survive the disease in one piece.  Every single day is an unbelievable roller coaster and a HUGE financial drain on most people.  When they get blood they can perk up and feel "better" and then suddenly they can either throw an embolism and just keel over or crash repeatedly literally in mere HOURS (about 4 times I saw Billy get blood on Day 1, only to crash again and have to have another transfusion in just a few days -- it's like it would 'hold' for a day or two and then sometimes just the mere transfusion itself would seem to set off the body killing blood cells all over again).

    In the space of about 5 weeks Billy had SIX transfusions.  And he was 18-20 months getting fully off the steroids.  He's been another year plus just recouperating FROM the steroids.

    The only real difference I can see with Billy's case than most others was the use of Traditional Chinese Veterinary Medicine (acupuncture and Chinese herbals) to help mitigate the damage from the drugs and to help his body manufacture blood.  He also took unbelievably high amounts of milk thistle to protect his liver and kidneys.

    You may want to search the archives here for IMHA and AIHA.  We will be supportive -- it is a horrible disease.  Many of us have been touched by it.

     


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  • 02-26-2009 11:46 AM In reply to Elie

    • JackieG
    • Top 25 Contributor
    • Joined on 04-15-2008
    • Central Texas
    • Posts 5,913
    • Points 710

    Re: AIHA disease

    I am so sorry you lost your Rosie.  Please be easy on yourself.  Rosie is no longer suffering and her life, if she could have been treated and saved, may not have ever been the carefree running and playing that she loved. Don't feel she was Taken from you.  She was Given to you to love for her time here and you did love her.  Every word of your post proves just how much you loved her and she knew that.  Please visit the Rainbow Bridge thread and you will see that she has so many wonderful companions now and she is probably playing with Christie.  Sending you hugs and prayers.  I have felt like you and know that only time will heal your heart.




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  • 02-26-2009 11:57 AM In reply to Elie

    • CoBuHe
    • Top 75 Contributor
    • Joined on 08-03-2007
    • Southeast Texas
    • Posts 2,529
    • Points 85

    Re: AIHA disease

    Elie:
    I feel that she was taken away from me because I did not give her the attention she craved.

    If I can say anything at all about your situation, it is this:  IT IS NOT YOUR FAULT.  Please do not blame yourself for her illness.  Its normal to feel tragically sad, devastated and even try to take on the guilt.  There is no one to blame.  Illnesses happen, and can sometimes be out of your control no matter what treatments are applied.

    You gave your sunshine love, shelter and the basics of necessities.  You sound like a wonderful fur mom.  Sometimes when things happen in life that out of our control, we blame ourselves.  But IT IS NOT YOUR FAULT.

    Rest in peace... little Rosie.  Hugs to you Elie.

    "No matter how little money and how few possessions you own, having a dog makes you rich." Louis Sabin
    ________________________
    Barbara, Proudly owned by
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  • 02-26-2009 12:56 PM In reply to CoBuHe

    Re: AIHA disease

    OH, Elie, we're all so sorry for your loss.  Such a tremendous devastation when our best friends are suddenly in misery and it's up to you to make such decisions.  But, in all honesty, you have to know that this was not your fault and you did not let Rosie down.  You were there for her in the most frightening, painful time of her life and as her friend, you helped take that pain and fear away so that she could cross over to a pain free life over the Rainbow Bridge.  There was nobody else more qualified to make that decision for her, and nobody else she would have wanted to make that decision for her, than you.  YOU were chosen to be with her in this life to give you both the joy you shared, and to bond you so well that you were the right person to help her cross over when she needed you.

    Please go easy on yourself.  AIHA is such a heart-breaker.  A friend's 3yr old dog that I had bottle-fed as a baby, suddenly lost her life because of it this past Thanksgiving, just two days after her house-mate died from cancer.  We understand the grief you feel in this bizarre disorientation of such a sudden illness. Peace be with you, your family who loved Rosie, and Rosie herself as she crossed the Rainbow Bridge and met dozens of dogs that will become her friends and companions until she sees you again.


    Paige - dog.community moderator & Gracie - 6yr old Doberman
    www.fortunatek9.com
    Fight for your opinions, but do not believe that they contain the whole truth, or the only truth. ~W. Hamilton
    "So you've 'had dogs all your life'? I've had teeth all my life. Doesn't make me a dentist." - JV McDonough, Certified Dog Trainer
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  • 02-26-2009 4:08 PM In reply to calliecritturs

    Re: AIHA disease

    calliecritturs:
    You may want to search the archives here for IMHA and AIHA.  We will be supportive -- it is a horrible disease.  Many of us have been touched by it.

    I was posting from work so I didn't get to 'read' what I wrote before I posted, and it almost sounds like I think "if you do" certain things they'll survive. 

    THEY *DO* ******NOT******

    It's completely capricious.  Last night I was in tears (with my husband) over Indiana, the golden that passed yesterday (IMHA has certainly been busy this last couple of months *sigh*).  There truly seems to be no rhyme nor reason to this disease ... Gratefuldawg, and others have been posting in that long 23 page thread JUST SO other people can see what does work ***SOME*** times.  All the time?  heck no.  why sometimes and not others?  No one knows.

    sometimes I really think one of the reasons Billy had to go thru this is just because I'm such a campaigner.  Because I don't know when to shut up and stop sometimes.  I keep trying to ENCOURAGE people, to help just a little bit more and to offer hope when it is do darned hard to have *any* at all. 

    Because IMHA is a heinous killer.  And then you tend to spend hours like Elie beating yourself up thinking you coulda/shoulda/woulda.

    DON'T Elie.  You did your best.  As someone above said YOU were *chosen* because your sweet girl needed to know she was loved.  It was nothing you did wrong.  You didn't ignore symptoms for weeks.  Often those beginning onset "symptoms" (the dog vomits ONCE) -- most of us don't think we CAN take a dog to the vet for throwing up *once* -- many vets would just laugh at us, but with IMHA it's all you get!!

    Please don't think she was 'taken' from you ... you did your best, and you did what is truly the ultimate act of love.  This is just a horrible, terrible heinous, vicious disease.  There are no crystal balls -- nothing to tell us how it will really go and sometimes ALL you can do is simply make the best decision you can at the moment.  She understands.  She loves you because you thought of HER, not of yourself.

      

     


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  • 02-27-2009 10:54 AM In reply to calliecritturs

    • Elie
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    • Joined on 02-26-2009
    • Posts 8
    • Points 185

    Re: AIHA disease

    I just keep wondering if I should have proceeded with more tests, etc. on Rosie. It was so overwhelming to hear from vet what was going on, I don't think I processed everything and now I am beating myself up that I should have fought harder. I fought with all my might for 8 years for my Dad, long time for my Mother, a year for my cat who passed away at age 19 with renal failure, and for all my other pets and tried to do the same for Rosie but I just feel right now that I did not do enough. When vet said base estimate would be $4,000. immediately and could go as high as $7,000. with more tests and the damage more medications could do, and no guarantee of survival or any quality of life afterwards or even within 48 hours, and when I saw her struggling to breathe even in oxygen cage, that is when I decided to let her go. Now I have regrets that I did not give her more chances to try and beat this. I am a fighter for anyone's life and I feel that I let her down. I know this is all in the grieving process but right now I don't feel any better. Within 4 years to the date, I lost my Dad, my dog Christie, my cat and my dog Rosie. Right now I am in misery. Thank you for all your concern.
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  • 02-27-2009 11:33 AM In reply to Elie

    Re: AIHA disease

    Elie -- my husband and I discussed this VERY thing last night at dinner. 

    Rightly or wrongly, vets often try to assess not only what the dog's chances are, but the realistic ability of what a client's finances can handle.  The costs of this disease can be beyond overwhelming (I think we put over that amount into Billy's first couple of weeks, much less the next month of intensive care so your vet was likely potentially pretty darned close.)

    If your dog was jaundiced already -- that tends to stack the deck WAY bad and not in their favor.  Simply because if the liver values are already bad then they can't consider azathiaprine (which is a far cheaper drug but well known to be VERY hard on the liver).  But the problem with cyclosporine is that it takes a LONG time to kick in -- weeks sometimes. And some dogs just plain don't have that kind of time.

    Elie -- truly -- do NOT beat yourself up.  I'm a fighter too -- and to quote Megan (Pirate's Mom) "I don't care if I eat Ramen Noodles for the rest of HIS life, I'll afford what I have to"), but the fact that your dog wasn't getting enough air to breathe sounds to me like either the heart and/or lungs were already struggling and there may already have been blood clots in the lungs or something else at work that was complicating what is already a VERY complicated disease. 

    You made the BEST decision you could.  Absolutely.  None of us have a crystal ball -- we can ONLY do what is our best guess at the time, and when an animal is in THAT much trauma, in complete honesty I would likely have done exactly the same thing. 

    I wish we'd known you a week ago -- if you'd felt like you got some extra counsel this might have made things easier for you *now* ... but for whatever it's worth, you made the best decision you could, and Elie, that is ALL any of us can ever do. 

    She went tripping over that Bridge fully aware that you loved her beyond all else.  That decision is THE hardest any of us ever have to make.  Remember the love, Elie.  It will help you.


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  • 02-27-2009 11:49 AM In reply to Elie

    • CoBuHe
    • Top 75 Contributor
    • Joined on 08-03-2007
    • Southeast Texas
    • Posts 2,529
    • Points 85

    Re: AIHA disease

    My heart is breaking for you Elie.  You made the right decision.  Please realize that.  The sooner you do, the sooner you can grieve and the sooner you can get on with this life and care for those here.

    Rosie is fine now...she is playing with my Codycoe and all the others at the Rainbow Bridge.

    "No matter how little money and how few possessions you own, having a dog makes you rich." Louis Sabin
    ________________________
    Barbara, Proudly owned by
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  • 02-27-2009 4:33 PM In reply to Elie

    Re: AIHA disease

    Elie, Callie just told me about Rosie.  I am a border collie person.  Rosie sounds like my dog Domingo.  This disease is horrible.  The ups and downs.  Your vets were honest about the cost.  I am at 4000.00 and even if things go well from now on it will be costing between 4 and 5 hundred a month for the medicine and bloodwork.  I'm not so sure about what he said that there is no chance for a normal life after AIHA.  Each dog is different.  Each situation is different.  

     Dogs don't blame people or have those kinds of feelings.  All dogs know is Love.  They love with each heartbeat until their heart can beat no more.  When you are ready I hope you'll consider finding another border collie at a border collie rescue.  Not all people can handle border collies and many of them get abandoned.  I can't think of a better way to honor Rosies memory than by rescuing a border collie from a border collie rescue.  Dog's don't hold grudges and I really think she'd want you to be happy again.

     I'm literally choking back tears right now.  My thoughts are with you Elie. please let me know if there is anything I can do.

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  • 02-28-2009 12:42 AM In reply to GratefulDawg

    • Elie
    • Not Ranked
    • Joined on 02-26-2009
    • Posts 8
    • Points 185

    Re: AIHA disease

    Thank you so much for all your concern. I really appreciate everyone's response to my unhappy outcome of Rosie. Her beautiful eyes, scamp personality, and a huge loving heart will always be in my memory. Life will never be the same without her but in the future I do plan on getting another border collie (hopefully just like her) to help make my life, my 9 yr old border collie's life, and my 2 yr old cat's life a little more pleasant in this home. Right now we are all devastated. Rosie was the sunshine in this family. Thanks again. Elie
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  • 03-05-2009 6:09 PM In reply to Elie

    Re: AIHA disease

    I THINK 99.9% OF ALL WHOSE DOGS DEVELOPE THIS HORRIBLE DISEASE FEEL GUILT, FEEL IT WAS THERE FAULT.  IN MY CASE I BLAMED MYSELF FOR "KILLING MY HUNTER" .  SO MUCH SO THAT I LOST 40 POUNDS IN 8 MONTHS.

     HUNTER WAS MY HEART DOG, MY BEAUTIFUL GOLDEN RETRIEVER AND THERE WAS A SPECIAL BOND BETWEEN US THAT EVERYONE SEEING US TOGETHER COMMENTED ON.  I WAS SO CAREFUL WITH HIS HEALTH, HIS WELL BEING AND I MADE THE DECISION TO SWITCH HIM FROM THE MONTHLY HEARTWORM PREVENTION PILL TO THE 6 MONTH INJECTION CALLED PROHEART6.  AFTER ALL, IT WAS SUPPOSE TO BE AS SAFE AS IS DRINKING WATER.  YEAH, RIGHT.

    HE GOT HIS FATAL INJECTIONON AUG. 28, 2003 AND DEVELOPED AIHA AND IT ALSO CAUSED SEVERE LIVER DAMAGE.  I LOST HIM AT 8:20 PM ON OCT. 16, 2003.  HE WAS 4 YEARS  AND 3 DAYS SHORT OF 2 MONTHS OLD.  AFTER HIS DEATH I START RESEARCHING AND FOUND STORY AFTER STORY (MNY RIGHT HERE) OF DOGS TAT WERE EITHER LOST OR ALMOST LOST TO PROHEART6.  A FEW LOST 2 DOGS.  I HAD CONTACT WITH ABOUT 45 WHOSE DOGS DEVELOPED AIHA FOLLOWING THE INJUECTION AND ONLY 2 WERE STILL ALIVE, A BUFF COCKER AND A BEAGLE.  I ALSO LEARNED THAT THERE HAD BEEN 3 CHANGES IN THE WARNING LABEL.  IN THE 2ED CHANGE, AIHA WAS LISTED AS AN ADVERSE REACTION, AND THE 3RD CHANGE--WHICH WAS DONE THE DAY HUNTER GOT HIS FATAL INJUECTION, DEATH WAS LISTED AS AN ADVERSE REACTION.

    I COULD ONLY THING IF I HAD KNOWN HOW TO USE A COMPUTER, HAD RESEARCHED IT BEFORE PUTTING HIM ON IT, I WOULD HAVE KNOWN IT WAS DEADLY AND I WOULD HAVE NEVER PUT HIM ON IT.  AND THEN ON SEPT. 3, 2004, JUST A LITTLE MORE THAN 10 MONHS AFTER HUNTER'S DEATH, THE FDA HAD FORT DODGE PULL IT BECAUSE OF THE HIGH NUMBER OF DEATHS.  IN THE 3 YEARS IT WAS ON THE MARKET, IT KILLED MORE DOGS THAN ALL THE OTHERS COMBINED--AND THE DAILY HAD BEEN OUT 25 YEARS, SOME OF THE MONTHLY OUT FOR 12 YEARS.   AIHA, LIVER DAMAGE, AND GASTRIC PROBLEMS WERE 3 OF THE LEAING REATCIONS THAT CAUSED DEATHS.  ONE LADY IN COLORADO LOST ONE OF HER DOGS TO AIHA, ONE TO LIVER, AND THE 3RD IS STILL ON MEDS 6 YEARS LATER FOR AUTOIMMUNE PROBLEMS.  ALL 3 HAD GOTTEN INJECTIONS THE SAME DAY.  ONE IN BOSTON LOST BOTH HER DOGS TO IT, ONE IN FLORIDA LOST ONE AND ALMOST LOST HER 2ED ONE.

    IT IS SO EASY TO FEEL GUILT AND THE "IF ONLY" AND "WHAT IF" AND THE TRUTH IS, ONCE THE DISEASE IS THERE, I DO NOT THINK EARLY TREATMENT MATTER.  ONE THING WE ALL FOUND OUT WAS THE DISEASE WAS REALLY HOLD OF OUR DOGS BEFORE WE REALIZED ANYTHING WAS WRONG. THEY SEEM TO JUST GO DOWN HILL UNTIL THE DRUGS TAKE EFFECT--IF THEY DO.  MY HUNTER HAD TRANSFUSIONS, ALL KINDS OF MEDS, BUT HE COULD NOT BEAT BOTH THE LIVER DAMAGE (DRUG INDUCED NECROSIS OF THE LIVER ACCORDING TO THE HISTOPATH REPORT) AND THE AIHA,.

     THIS IS MY HUNTER AND MY OLDEST SON.

     

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  • 03-11-2009 1:47 PM In reply to GratefulDawg

    • Elie
    • Not Ranked
    • Joined on 02-26-2009
    • Posts 8
    • Points 185

    Re: AIHA disease

    Hi: Thank you for your nice letter. I love border collies although when I said to both of them just a couple of days before Rosie got sick that I wished I had Westies instead because at that time they were driving me nuts --- the older one (Hollie) wanted out but would not go out --- Rosie wanted out but then would not come in --- and this went on and on for a long time. Now I feel bad that I ever said that. Now I am wondering if a bug or tick got into Rosie's bloodstream and caused this AIHA problem. I quit giving them flea/tick medicine on their necks a long time ago because both dogs were sick for a couple of days afterwards. I never had a flea/tick problem before, they were never scratching or biting --- always put garlic salt on their hamburgers or put it on rump roast when I cooked it. Actually they hadn't had any garlic salt for a couple of weeks because I was feeding them more chicken and boiling the ground meat, trying to cut their weight down --- not so much Rosie but Hollie was getting porky. Hollie's main goal in life is to eat. Rosie was biting her rear just a couple of days before she showed any sign of illness and now I keep thinking something bit her and got into her bloodstream. I am beating myself up over this because I wouldn't have hurt her for the world and now think that due to my negligence she got ill and died. Rosie always wanted to spend more time outside running, playing, and laying under the bushes whereas Hollie could care less about that now since she is older. It is an awful life without her and especially thinking that it was my fault for all of this happening to her. She was so beautiful inside and out. Elie
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  • 03-11-2009 2:11 PM In reply to Elie

    Re: AIHA disease

    My sweet border collie mix Zoya died of this horrible disease at 9 years old.  We tried everything also, several transfusions, steriods, you name it....  There is nothing you can do to stop it.  It's awful.  She died 3 weeks after being diagnosed, we had to finally give up and let her go, but we still wondered if we did the right thing.  I now know we did, and you did also.    You did everything you possibly could, and you were there for her when she needed you.  Take comfort in knowing you loved her and she loved you right back.

     

     

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