I've not done that, nor would I, but I think you need to trust your instincts. If you really think one of your dogs can't handle it, you should probably try to simulate the quarantine situation somehow using a boarding facility that is used to large breed dogs with similar issues. If she can't handle it for a short period, a long one could be a mess. But, if she does ok, you could repeat several times so that she gets used to being away, and yet knowing that you will always come back for her.
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"If you talk to the animals they will talk with you and you will know each other. If you do not talk to them you will not know them and what you do not know, you will fear. What one fears, one destroys." - Chief Dan George
"The fidelity of a dog is a precious gift demanding no less binding moral responsibilities than the friendship of a human being. The bond with a true dog is as lasting as the ties of this earth can ever be." ~ Konrad Lorenz