The liver problem was only diagnosed last year -- however you say this has been going on for 'years' and I have a feeling you're gonna ultimately find that the vulvar skin problem is RELATED somehow to the liver problem.
When she 'acts sick' that's because the liver isn't filtering out the toxins. When a dog is in renal failure (kidneys) and the kidneys don't filter out toxins the dog gets nauseus because the toxins pour into the stomach, ulcers develop etc.
However, liver toxicity is 'different'. Liver toxins actually shunt directly to the brain -- so when liver toxicity becomes evident (and the dog 'acts sick') it's really the brain TELLING the gut there is nausea, not that there IS true nausea. Fine difference but one to be treated completely differently.
There is a medicine called "lactulose" -- it's actually a laxative, BUT it's often used in liver problems because it binds liver toxins and helps get them out of the body RATHER than them ending up shunting to the brain and staying there. It's a tough med to take -- they can take pretty huge doses of it BUT it **IS*** a laxative, so of course the more they take the more diarreha they get so it's pretty well a double-edged sword.
I'm pretty famliar with liver problems AND with the remedies that go with them. I had a dog who virtually in a few hours developed a ENORMOUS liver infection. It was at first diagnosed as "liver failure" -- old dog, looked like cancer, gee take him home and get him put to sleep (that's what they told me at the e-vet). They put him on an IV drip with antibiotics *just in case* and essentially didn't bother to listen to me. The x-ray of the liver was DIRE. It looked so bad -- truly it did. How could he survive with a liver that looked like that!! (swollen, uneven, bad bad texture, generally looked really horrific)
But they weren't listening to me when I told them he'd eaten something extremely toxic -- I knew the dog I knew the symptoms I saw and my own vet (the next morning) and HE ... knowing me and how incredibly hands-on I am and how much I 'notice' -- essentially he put him on antibiotics just to pacify me.
I took him to my holistic vet the next day -- and she confirmed everything I already suspected. She looked deeper into the records -- that there were dozens of small signs that this WAS an infection.
So -- to supplement what the regular vet gave him, she added liver supplements, and milk thistle AND A chinese herb that mimics milk thistle.
WHOA -- in a few days I had a new dog. Well still a 17 1/2 year old dog at that time but an almost completely recovered dog.
My point is this -- PLEASE don't sell integrated medicine short. I'm not telling you to leave your regular vet. I'm telling you to AUGMENT the care -- acupuncture helps healing, acupuncture helps detox the body, and acupuncture can generally put the body on a faster track to heal. I've had incredible experiences with Chinese herbs (both with the dogs AND me) and how they can *augment* regular veterinary medicine.
My other thot on this one is the thyroid. The thyroid is a body balance thing -- and it can feed into liver problems and adrenal problems (Lupus, Cushings -- yep, diseases like that which can be fatal if untreated but which can be incredibly well managed if caught). But if the thyroid is 'off' nothing you do will help.
DON'T just have the vet send a lab test in -- it's pointless. A regular lab assumes all breeds are 'alike'. You get back one result that's a pass/fail for all breeds. A chihuahua and a labrador are completely different metabolically. A rottie and a vizla ... a cocker and a whippet -- none of them are the same -- size doesn't matter -- body metabolism does.
have the vet send the results to either Dr. Jean Dodds directly or to Michigan State University -- Dr. Dodds set up MI's lab and they use her protocols. This isn't weirdo stuff -- this is just incredibly accurate.
Your ID says you are in NV -- again I'm going to ask a couple of questions. Would you happen to have St. Augustine sod? Would you happen to have night-blooming jasmine, wandering jew (any one of 100 varieties either as an indoor houseplant or as a climbing weed, planted as ground cover, etc. outside or anywhere one of the resident HUMANS could possibly have contact with anything like that?), or poison oak?
The 'root' of the skin problem could well be contact allergy. She's thick-coated and may not 'show' irritation elsewhere -- but it sure could bother a female who dips and squats in/on a plant that is an irritant, OR who may lay on her belly IN THE HOUSE where someone has walked who has walked thru an irritant.
The fact that you bathe her frequently may keep it from spreading elsewhere. But that skin is SO tender and sore and bless her heart she's gotta pee.
That's just another 'thot' for you in any event.
There are two ways a sterile urine draw can be done for a urinalysis and honestly, I think the above is right -- you probably DO need a sterile urine culture done.
The second way is by cathether (and most vets generally prefer to do it that way -- at least ones I've worked with and my Billy has had probably 6 or 8 of them in the past 6 months). The big deal is when you take a 'caught' urine specimen, the urine is going thru the urethra that's essentially passing over sore skin that may also be infected. So doing the sterile urine draw is likely the ONLY way you'll get a true sample.
A culture & sensitivity doesn't just look to see if there are infection cells present. It actually cultures the urine to see what will 'grow'. THEN after they see what will grow they see what different drugs will KILL whatever grew. Not just one drug but many -- so the vet gets back a report that says ok, amoxyl, cephalexyn, Baytril, Cipro, etc. will all work, BUT drug B was fastest or whatever. Then the vet looks to see which drug goes thru what organs and which one is the hardest/least nasty on the liver. It gives you very specific results.
Did they ever come up with what caused the liver to be so insufficient?? That would concern me -- that could also be your target as to why the body was putting out so many toxins that could have started this skin infection that you never get rid of.
The biopsy idea also may have merit but it's hard on the dog -- biopsies don't just diagnose cancer -- they take an actual section of skin (not just a scraping but a cross-section of skin) and analyze it. Not cheap again, but it gives you more definite results.
See, I'm not anti -traditional medicine, but I can promise you that PARTICULARLY when you are dealing with an organ like the liver which can be encouraged to regenerate boy I'd be at a TCVM vet in a heartbeat if I were you. It could potentially make the problem go away from the inside.
And bless your heart -- you bathe this girl every day -- I KNOW what kind of a commitment that is to a dog. I KNOW how much time that takes. What I'm saying may actually ultimately reduce all that effort and concentrate it where it will make a huge difference. Even if you've never 'been a believer' in alternative medicine -- I can cite you time and time again when I've seen it do awesome things. All my experiences started at the U of Florida where they actually teach both acupuncture and Chinese herbals. That's pretty broad-thinking for a 'state university'. But they see it work.
Good luck.